The goals of aging biology research are broad and ambitious—to understand how a multitude of genes, pathways and mechanisms at multiple scales contribute to declines in function, health and lifespan ...

Systems-level thinking has transformed how we study life across scales, from molecules and cells to populations, communities ...

Collective behavior in biological systems emerges from local interactions among individuals, enabling groups to adapt to dynamic environments. Traditional modeling approaches, such as bottom-up and ...

Modeling complex systems When studying complex biological systems such as the immune system, scientists can extract many different types of data. Sequencing cell genomes tells them which gene variants ...

Oscillatory dynamics in fundamental biological processes, such as circadian clocks, segmentation and transcription factor responses, requires precise quantitative control for proper cell regulation ...

Ever better experimental techniques allow us to perform experiments under tightly controlled conditions and can deliver gigantic amounts of data reflecting the complexity of biology. This has vastly ...

Cells naturally process external signals through intricate genetic circuits, enabling the adaptation to diverse environments. These circuits rely on complex, nonlinear interactions among genes and ...

When viewed from an engineer's perspective, biology is often messy and imperfect. For example, redundancy is a common feature of biological systems, with the job of one biological component ...

Systems biology is a rapidly evolving discipline that examines the complex interactions underlying biological function ...

Christina A. Sheil, MD, explains why polypharmacy has become one of the most significant challenges in modern healthcare.

In 2020, researchers engineered living, programmable organisms from Xenopus laevis, calling them xenobots, which could self-assemble and even reproduce. Building on this work, scientists later ...