Nature

Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery

Herpesviruses are a leading cause of human viral diseases, including oral and genital blisters (herpes simplex viruses HSV-1 and HSV-2), chicken pox and shingles (varicella zoster virus), and cancers ...
Nature

Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland

Although the potential for therapeutic gene transfer by replication-deficient Ad has resulted in extensive investigations of its toxicity and immunogenicity, less information is available on the ...
Science Daily

Wit, grit and a supercomputer yield chemical structure of HIV capsid

Researchers report that they have determined the precise chemical structure of the HIV capsid, a protein shell that protects the virus's genetic material and is a key to its virulence. The capsid has ...
Labroots

Researchers Solve the Structure of the HIV Capsid, May Be a New Drug Target

Though treatments are available, there is no cure or vaccine from HIV, which impacts about 38 million people worldwide. It's difficult to target the RNA genome of the HIV virus in part because it ...
The Independent

Inside the Aids virus: Research finds chink in the armour that protects HIV in breakthrough that could lead to a new class of drugs

Scientists have for the first time built a detailed molecular model of the shell-like “inner sanctum” within the Aids virus, opening the door to potential new treatments. The cone-shaped “capsid” is ...
GEN

Technique Solves HIV Capsid Structure; Could Serve as Blueprint for Capsid-Targeting Antivirals

Scientists at the Electron Bio-Imaging Centre (eBIC) at Diamond Light Source, in the U.K., have harnessed a new technique, using cryo-electron tomography (cryoET) and subtomogram averaging (STA) to ...
University of Delaware

New insights into HIV

HIV, the virus that causes AIDS, has been studied extensively ever since the AIDS epidemic was officially recognized by health professionals in the early 1980s. During that time, research has led to ...
Business Wire

Gilead Presents Data on Investigational HIV-1 Capsid Inhibitor GS-6207 as a Potential Component of Long-Acting HIV Therapy

FOSTER CITY, Calif.--(BUSINESS WIRE)--Gilead Sciences, Inc. (NASDAQ:GILD) today announced data on GS-6207, an investigational, novel, selective, first-in-class inhibitor of HIV-1 capsid function, that ...
Business Wire

Gilead Presents Proof-of-Concept Data for GS-6207, a First-in-Class Capsid Inhibitor, in People Living With HIV

FOSTER CITY, Calif.--(BUSINESS WIRE)--Gilead Sciences, Inc. (NASDAQ: GILD) today presented the first clinical data in people living with HIV on GS-6207, an investigational, novel, selective, ...
The Verge

Supercomputer-powered HIV research brings new hope for more effective vaccines

Finding an effective, safe HIV vaccine is still an ongoing struggle for scientists, but a new, supercomputer-aided discovery is offering a new hope. Researchers from the University of Illinois and the ...
Nasdaq

Gilead Presents Proof-of-Concept Data for GS-6207, a First-in-Class Capsid Inhibitor, in People Living With HIV

– Phase 1b Study Demonstrates Potent Antiviral Efficacy Following a Single Subcutaneous Injection of GS-6207, No Discontinuations Due to Adverse Events – FOSTER CITY, Calif.--(BUSINESS WIRE)-- Gilead ...