A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off ...

A public-data reanalysis identified broad tumor-normal gene-expression changes in sinonasal squamous cell carcinoma and ...

"This review closes a scientific circle that began for me in 1989, when we helped demonstrate that the machinery controlling normal cell division could be directly connected to oncogenic ...

Researchers at Roswell Park Comprehensive Cancer Center have identified a promising strategy for overcoming one of the ...

Drugs targeting the protein Wee1 looked promising, but an incomplete understanding of their mechanism likely led to the ...

Wee1 inhibitors are a promising new cancer treatment, but serious side effects threaten their adoption in the clinic. Now, ...

The review emphasizes how breakthroughs in understanding the molecular mechanisms of cell cycle regulation have paved the way for the development of targeted anti-cancer agents. Notably, inhibitors of ...

In a tale of identities as divergent as "The Prince and the Pauper," a well-known cancer-causing gene also influences cells in a zombie-like state meant to prevent cancer. Scientists at Sanford ...

Researchers at Roswell Park Comprehensive Cancer Center have identified a promising strategy for overcoming one of the biggest challenges facing KRAS-targeted cancer therapies: treatment resistance.

Stopping tumor growth is only half the battle. Rather than killing tumor cells, many cancer therapies can only push them into cellular senescence, a state in which cells stop dividing but do not die.

As CAR-T therapies continue to evolve, improved care coordination, earlier patient referrals and enhanced support systems can ...