Segmental copy-number gains are major contributors to human genetic variation and disease, but how these alterations arise remains incompletely understood. Here, based on the analyses of both ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life; however, existing approaches face limitations mainly due to their ...