We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

An algorithm for linear mixed models substantially reduces memory usage and run time for genome-wide association studies. The improved algorithm scales linearly in cohort size, allowing the ...

Scientists may wish to analyze correlated outcome data with constraints among the responses. For example, piecewise linear regression in a longitudinal data analysis can require use of a general ...

Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability ...

Just as PROC GLM is the flagship procedure for fixed-effect linear models, the MIXED procedure is the flagship procedure for random- and mixed-effect linear models. PROC MIXED fits a variety of mixed ...