We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

However, the utility of linear (mixed) models in the context of meta-analysis of GWAS of binary phenotypes has not been previously explored.

Scientists may wish to analyze correlated outcome data with constraints among the responses. For example, piecewise linear regression in a longitudinal data analysis can require use of a general ...

Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability ...

Just as PROC GLM is the flagship procedure for fixed-effect linear models, the MIXED procedure is the flagship procedure for random- and mixed-effect linear models. PROC MIXED fits a variety of mixed ...