Intestinal epithelial cells (IECs) are more than a passive barrier; they serve as non-professional antigen-presenting cells by expressing major histocompatibility complex class II (MHC class II) ...
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4+T cells ...
Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...
Researchers found that T cells recognize neoself-antigens -- abnormal, unfolded host proteins presented by major histocompatibility complex II (MHC-II) lacking the invariant chain -- as non-self ...
A new study finds that calreticulin, long considered an essential chaperone for MHC class I antigen presentation, is functionally expendable in that role, with oncogenic variants and calreticulin ...
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