Single-Molecule Localization Microscopy (SMLM) has traditionally faced challenges to optimize signal-to-noise ratio, penetration depth, field-of-view (FOV), and spatial resolution simultaneously. Here ...

In this way, and almost by chance, researchers at TU Wien developed a novel microscopy technique that allows the refractive index of biological samples to be measured at a resolution far below what ...

How do photosynthetic organisms harvest light so efficiently? To help answer this question, researchers have developed an ultrafast transient absorption microscope with sensitivity approaching the ...

Current methods for single-molecule orientation localization microscopy (SMOLM) require optical setups and algorithms that can be prohibitively slow and complex, limiting widespread adoption for ...

When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

Standard genetic sequencing approaches can tell you a lot about the genetic makeup and activity in a sample, like a piece of tissue or drop of blood. But they don’t tell you where specific genetic ...

A decade ago, the Nobel Prize in Chemistry was awarded to a trio of researchers for the development of super-resolved fluorescence microscopy. The announcement at the time stated that the researchers’ ...

The original goal was to investigate biological samples on a molecular scale – but this soon led to stubborn technical problems. Eventually, however, the researchers realized that the very source of ...

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules. DNA is a molecule found in just about every living cell. Because ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Listed in the Guinness World Records, this tiny electric motor needs a special kind of microscope capable of making out a ...

Leo Gross is a physicist who has devoted his career to studying the fundamental secrets of chemistry—that is, how atoms and molecules behave and interact with one another. As leader of IBM’s atom and ...