The NFC West has turned into a three-headed monster this season with the Los Angeles Rams, Seattle Seahawks and San Francisco 49ers winning boatloads of games and fighting for first place. Then there's the sorry state of the Arizona Cardinals.

The Arizona Cardinals are back in action in Week 11, facing the San Francisco 49ers for the second time this season. The 6-4 49ers and 3-6 Cardinals kick off from State Farm Stadium in Glendale, Arizona at 4:05 p.m. ET (2:05 p.m. Arizona time).

The Arizona Cardinals were destroyed by the Seahawks last week but they have a chance to get back on track in Week 11, with the 49ers coming to town.

The Arizona Cardinals suffered another blowout loss. On Sunday at State Farm Stadium, they gave up a 98-yard kickoff return to start the game and fell behind 14-0. Jacoby Brissett set an NFL record with 47 pass completions, but he threw two interceptions, and the 49ers dominated, cruising to a 41-22 victory.

Find single game tickets to the San Francisco 49ers vs. Arizona Cardinals NFL Week 11 matchup on Sunday, November 16, 2025 at State Farm Stadium.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

No. 6 seed in the NFC playoff race during their Week 14 bye as key results around the conference shake up the postseason picture.

San Francisco gets to No. 6 no matter how this game finishes. The 49ers would move ahead of the 8-4-1 Packers if Chicago wins. They'd jump over the No. 7 seed 9-4 Bears to No. 6 if Green Bay wins. A loss from one of the Seahawks or Rams would push the 49ers up to No. 5, ahead of the NFC West team that lost and ahead of the loser of Packers-Bears.

The Los Angeles Rams were looking to get back on track today after getting stunned by the Carolina Panthers a week ago. At 9-3, they were still leading the NFC West but they were chasing the Chicago Bears for the top seed in the conference.

How Week 14 games impact San Francisco's NFC seeding, postseason path, and key rooting interests in a tight playoff race.

After starting the season with a 9-4 record, the San Francisco 49ers take on the Tennessee Titans. Here's a look at the betting odds.