New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase. Telomerase's only known role in normal tissue was to protect certain ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Of the many components in the cell thought to play a role in cancer, few have received more attention in recent years than an enzyme that has been dubbed a cellular fountain of youth. Known as ...

Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT. Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we report biochemical and ...

Biochemists have produced a three-dimensional structural model of telomerase's RNA "core domain." Telomerase is an enzyme that helps maintain telomere DNA -- the DNA found at the very ends of ...

In an effort to understand and control telomerase activity, researchers have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts ...

MENLO PARK, Calif.--(BUSINESS WIRE)--Geron Corporation (Nasdaq:GERN) today announced the publication of preclinical data on TAT2, a small molecule telomerase activator. The studies show that human CD8 ...

For the very first time, a study led by Julian Chen and his group in Arizona State University’s School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution, has ...

Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.

The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown. We report that the Schizosaccharomyces ...

Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to ...

Telomerase promotes proliferation of resting stem cells through a mechanism that does not involve the extension of chromosomal telomeres, researchers report in Nature this week. "This is a completely ...