An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Molecular-Level Dissection ...

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within ...

Around 2015, Katherine Chiappinelli was investigating the mechanism behind a group of drugs approved to treat blood cancers—and showing promise against other cancers—when she made a puzzling discovery ...

Transposable elements are DNA sequences which are also known as “jumping genes”, given their ability to move from one location of the genome to another. They are present in all eukaryotic genomes and ...

Raíssa Mesquita Braga, Mateus Ferreira Santana, Rodrigo Veras da Costa, Sergio Herminio Brommonschenkel, Elza Fernandes de Araújo and Marisa Vieira de Queiroz Transposable elements are ubiquitous and ...

Ancient viruses are embedded everywhere in the human genome. Estimates range, but it's thought that about eight percent of the human genome could be made up of these ancient retroviruses, which are ...

Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have puzzled ...

Around 45 percent of human DNA is made up of transposable elements, or TEs—genetic leftovers from now-extinct viruses that scientists once believed to be “junk DNA.” But that view is changing, and a ...

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors ...

New research from scientists at Cleveland Clinic’s Genome Center and their collaborators at other institutions describes a pathway that human herpes simplex-1 (HSV-1) can use to contribute to the ...

The discovery in maize of jumping genes, also known as transposable elements, revolutionised our perception of genome organisation across kingdoms. Transposable elements are mobile small repetitive ...

While mutations can arise in the genome and have little consequence, sometimes they are beneficial and selected to remain in an organism. In most cases, genetic errors have negative consequences for ...