Gut

Beyond the usual suspects: haemorrhagic shock secondary to massive obscure gastrointestinal bleeding

A 49-year-old woman with alcohol-related cirrhosis (Child-Pugh B8, MELD 11) and 11 months of abstinence presented with per ...
Gut

KIF13B emerges as a key player in alcohol-associated liver steatosis

Alcohol-associated liver disease (ALD) is a major global health problem and a leading cause of liver-related morbidity and ...
Gut

Tissue-regulatory T cells influence anti-cancer and pro-repair functions in the exocrine pancreas

Background Regulatory T cells (Tregs) are fundamentally important for maintaining immune homeostasis, and their potent immune ...
Gut

Beyond Spigelman: time-adaptive duodenal cancer risk in familial adenomatous polyposis – results from a retrospective two-centre study (DRACO)

Background Duodenal cancer is a leading cause of cancer-related mortality in familial adenomatous polyposis (FAP), yet the ...
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Cardiovascular complications of cirrhosis

Department of Clinical Physiology 239, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark Associate Professor S Møller, Department of Clinical Physiology, 239, Hvidovre Hospital, DK-2650 ...
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Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation

BACKGROUND Thrombocytopenia in cirrhotic patients may be due to deficient production of thrombopoietin. AIMS To determine the relation between thrombopoietin and thrombocytopenia in cirrhotic patients ...
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The management of immunosuppression in patients with inflammatory bowel disease and cancer

1 The Dr Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA If you wish to reuse any or all of this ...
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Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis. Data sources We conducted searches ...
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PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial

3 Department of Paediatrics, Meander Medisch Centrum, Amersfoort, the Netherlands 4 MediServ BV/Clinical Research facilities BV, Schaijk, the Netherlands Correspondence to: Dr W P Voskuijl Department ...
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Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period

1 Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands 2 Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands 3 Department ...
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SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication

Background: Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.
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Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis

Background and aim: There are limited evidence based data concerning the use of azathioprine in ulcerative colitis. We aimed to compare the efficacy of azathioprine and oral 5-aminosalicylic acid in ...