Early cardiopulmonary resuscitation (CPR) and defibrillation improve survival after out-of-hospital cardiac arrest, but ...

Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase and regulates triglyceride-rich lipoprotein metabolism. MAR001 is a monoclonal antibody against ANGPTL4 that is being evaluated for ...

Corporations that make and market health-harming products are a primary vector for the global increase in mortality related to noncommunicable diseases. Research using internal industry documents c ...

For patients with moderate aortic stenosis, current guidelines recommend clinical surveillance with echocardiographic ...

Retatrutide, an investigational triple agonist of GIP, GLP-1, and glucagon receptors, may be useful for the treatment of painful knee osteoarthritis in persons with obesity. In two phase 3 trials, ...

Pelacarsen, an antisense oligonucleotide, reduces serum levels of lipoprotein(a). However, the effect of pelacarsen on cardiovascular outcomes remains uncertain. We conducted an international, ...

Obesity is the most common chronic disease in the world.1 Even more devastating are its sequelae, which range from sleep ...

The U.S. health care system still can’t identify medical harm as it occurs. But it’s now possible to develop systems that ...

In three patients with refractory epilepsy, hippocampal chemogenetic therapy plus low-dose clozapine was associated with a mean seizure-frequency reduction of 92.6%. Adverse events were grade 1 or 2.

The hallmarks of necrotizing fasciitis are friable superficial fascia, gray exudate without pus, and widespread tissue destruction. The infection is either polymicrobial or monomicrobial. Early ...

When patients, or the parents of patients, become heavily invested in searching for someone to blame for an illness, it’s useful to ask what the search is doing for them. Its accuracy is rarely ...