Cueva de Ambrosio, or Ambrosio Cave, harbors more than 70 red-and-black drawings of geometric shapes as well as mythological and human figures scattered throughout its five interconnected galleries.

This correspondence between brain state and brain responsiveness (statedependent responses) is outlined at different scales from the cellular and circuit level, to the mesoscale and macroscale level.

We conclude that brain states are shaped by local circuit mechanisms, large-scale connectivity and neuromodulation. A unified multiscale theory of cortical dynamics is relevant not only for ...