BMJ

Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to ...

Background: Optimal use of disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate (MTX) and sulfasalazine (SASP) are ...
BMJ

Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017

Correspondence to Professor Lingyun Sun, Department of Rheumatology and Immunology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210008, China; ...
BMJ

Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial

Background The efficacy of oral prednisolone in patients with active ankylosing spondylitis (AS) has not been studied to date. Methods In this double-blind, randomised, placebo-controlled trial, ...
BMJ

Inflammation in ankylosing spondylitis: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging

Background: Magnetic resonance imaging (MRI) is increasingly used to detect inflammation in the spine of patients with ankylosing spondylitis (AS). Objectives: To detect differentially the presence ...
BMJ

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined ...

11 Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA Correspondence to Susan Manzi, Allegheny Singer Research Institute, West Penn Allegheny Health System, Temple University ...
BMJ

Diagnosis and management of adult onset Still’s disease

1 Department of Medicine, Division of Allergy, Immunology, and Rheumatology, New Jersey Medical School, UMDNJ, Newark, NJ 07101, USA 2 Department of Medicine, Weill Medical College of Cornell ...
BMJ

Suprascapular nerve block (using bupivacaine and methylprednisolone acetate) in chronic shoulder pain

Correspondence to: Dr M Shanahan, Rheumatology Research Unit, Repatriation General Hospital, Daw Park, South Australia, Australia 5041; michael.shanahan{at}rgh.sa.gov.au. Background: Shoulder pain ...
BMJ

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

1 Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany 2 Department of Orthopaedic Trauma Surgery, University of ...
BMJ

SAT0463 The Prevalence of Knee Osteoarthritis Estimated by Validated Screening Questionnaire in The General Population of Singapore

Background Knee osteoarthritis (OA) is one of the leading causes of disability worldwide. The prevalence of knee OA is higher in Chinese than Caucasian subjects, despite the lower body mass index in ...
BMJ

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...
BMJ

Measurement properties of the ASAS Health Index: results of a global study in patients with axial and peripheral spondyloarthritis

Objectives To evaluate construct validity, interpretability, reliability and responsiveness as well as determination of cut-off points for good and poor health within the original English version and ...
BMJ

Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment

Objective: To create minimal disease activity (MDA) criteria for psoriatic arthritis (PsA). With recent therapeutic advances, this is now a goal for treatment and may represent a measure to compare ...