Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

The high clinical failure rate of small-molecule drugs is inarguably attributable to the lack of reliable predictions of chemical structure–efficacy–toxicity relationships that are applicable to ...

We herein disclose a mild and efficient cadmium-catalyzed domino reaction for accessing 1,6-enynes via a sequential A 3 -coupling/1,5-hydride transfer/hydrolysis/A 3 -coupling. This method ...

Protein–ligand binding affinity may be affected by protein mutations, especially point mutations occurring within the binding site, which may indirectly contribute to interindividual differences in ...

Low loose bulk density, a characteristic commonly observed in large accumulations of needle-like crystals, has caused numerous issues in both production processes and daily life. Antisolvent ...

The technological development of naturally occurring gas hydrates and related scientific research require safe and efficient field operations carried out by engineers. Scientific knowledge obtained in ...

ConspectusPhotovoltaics (PVs) are currently the most economical and location-independent source of electricity generation, and their demand is growing rapidly as a sustainable renewable energy source.

In this study, we report the development of a wearable tattoo sticker designed for rapid and noninvasive detection of γ-hydroxybutyrate (GHB), which is commonly associated with drug-facilitated sexual ...

Colloidal particles can co-assemble into multicomponent ordered superstructures, with their properties determined by the individual building blocks. Here, we demonstrate that covalent organic ...

Personal care products, such as cosmetics, have received attention for containing per- and polyfluoroalkyl substances (PFAS), yet limited information is known on the PFAS content in reusable feminine ...

Disinfection byproducts (DBPs) are formed during drinking water treatment from the reaction of chemical disinfectants with natural organic matter (NOM), anthropogenic contaminants, and inorganic ...

Pt-based binary intermetallic materials have been a main driver advancing electrocatalysis of fuel cell electrode reactions. Incorporating a third element into binary compositions has proven effective ...