Editor-in-Chief Jeffrey M. Drazen, M.D., highlights three of the Notable Articles of 2016 published in the New England Journal of Medicine: incidence of dementia in the Framingham Heart Study, a randomized trial of labor induction in women over 35, and a 10-year outcomes study in men with prostate cancer. Access the collection at nejm.org/nejm-special. | The New England Journal of Medicine