Heart Transplant Timing: How Long Can a Donor Heart Survive? Once removed from the donor’s body, a heart must be preserved in a cold, oxygen-limited environment to slow metabolism and prevent tissue damage. Medically, the safest ischemic preservation window is about 4–6 hours, during which the heart should be transplanted into the recipient. Shorter transport times improve outcomes because prolonged ischemia increases the risk of graft dysfunction and complications. #HeartTransplant #CardiacSurg
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